{"product_id":"tris-nac-sterilen-raztvor-s-visoka-yonna-aktivnost-120-ml","title":"Tris-Nac - sterile solution with high ionic activity 120 ml","description":"\u003cp\u003e• What is a biofilm?\u003cbr\u003eAn aggregate of bacterial cells encased in an extracellular matrix of polymeric substances that protect bacteria from\u003cbr\u003eantibiotics, chemical products, and the body's immune system. It can form on medical\u003cbr\u003einstruments and devices, as well as on body tissues.\u003cbr\u003eThis creates resistance to antibiotic therapy: bacteria embedded in a biofilm can be 100 to\u003cbr\u003e1000 times more resistant compared to \"free\" bacteria.\u003cbr\u003eSome bacterial species can produce biofilms. These include Staphylococcus pseudintermedius, Pseudomonas\u003cbr\u003eaeruginosa (especially in otitis in dogs, Figs. 1 and 2), Proteus mirabilis, Escherichia coli.\u003cbr\u003eIn the case of yeasts, Malassezia spp. can also form biofilms, particularly in cases of seborrheic dermatitis in\u003cbr\u003edogs.\u003cbr\u003eTherapy: topical therapy is one of the most innovative and includes not only the use of effective products but also\u003cbr\u003etheir combination to synergize their activity.\u003cbr\u003e• TRIS-EDTA (Ethylenediaminetetraacetic acid):\u003cbr\u003eHas a bactericidal effect on non-growing cells in the biofilm (Ciofu et al, 2017). The combination of EDTA with Tromethamine (TRIS)\u003cbr\u003eleads to damage to the cell wall and increases penetration through the cell membrane. It is well tolerated, not\u003cbr\u003eototoxic, and synergistically interacts with chlorhexidine (Guardabassi et al, 2010). A recently conducted in vitro experiment showed\u003cbr\u003ethat Tris-EDTA is a very effective aid in the treatment of chronic Pseudomonas otitis with potential biofilm presence\u003cbr\u003ewhen combined with antibiotics (Pye et al, 2014).\u003cbr\u003e• NAC (N-Acetyl Cysteine):\u003cbr\u003eThe N-acetylated derivative of the amino acid cysteine has a mucolytic action. By disrupting the production of\u003cbr\u003eexopolysaccharides (EPS), it weakens the matrix EPS. NAC has been used in eight clinical studies as\u003cbr\u003eadjunctive therapy to disrupt existing biofilm and prevent its formation, showing excellent\u003cbr\u003eefficacy and a safe profile. The combination of Tris-EDTA and NAC, applied to the skin or in the ear before applying\u003cbr\u003etopical products such as chlorhexidine, antibiotics, and synthetic antimicrobial peptides allows for increasing\u003cbr\u003ebiofilm permeability and its subsequent disintegration. This effectively overcomes the problem of\u003cbr\u003eresistance in the classical antibacterial therapeutic approach.\u003cbr\u003eInstructions for use:\u003cbr\u003e1. Press down on the top of the bottle until\u003cbr\u003ethe capsule breaks completely.\u003cbr\u003e2. Shake the vial.\u003cbr\u003e3. With the syringe provided in the package, withdraw\u003cbr\u003ethe necessary amount, following the instructions of a veterinarian.\u003cbr\u003eIn the ear canal: rinse thoroughly and massage the base of the ear.\u003cbr\u003eOn the skin: rinse until the affected area is thoroughly wet.\u003cbr\u003eRepeat treatment as needed or follow\u003cbr\u003ethe instructions of a veterinarian.\u003c\/p\u003e","brand":"ICF","offers":[{"title":"Tris-Nac - sterile solution with high ionic activity 120 ml","offer_id":55154401804662,"sku":null,"price":25.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0709\/9881\/9105\/files\/7848e5456f90f8c10a8aa2310c8f5fc8.jpg?v=1758722525","url":"https:\/\/zoomagazin.eu\/en\/products\/tris-nac-sterilen-raztvor-s-visoka-yonna-aktivnost-120-ml","provider":"zoomagazin.eu","version":"1.0","type":"link"}