THERAPEUTIC INDICATIONS: For the treatment and prevention of dogs infested with fleas (Ctenocephalides felis, Ctenocephalides canis).
Fleas on dogs die within 1 day after treatment. One treatment prevents re-infestation within 4 weeks. The product can be used as part of a flea allergy dermatitis (FAD) control program. The product has a persistent acaricidal and repellent effect for 4 weeks against Rhipicephalus sanguineus and Ixodes ricinus, and three weeks against Dermacentor reticulatus. Ticks that are already on the dog may not be killed within two days after treatment and may remain attached and visible. Therefore, it is advisable to remove ticks already on the dog immediately before treatment. One treatment provides repellent activity (protects against bites) against sandflies Phlebotomus papatasi for two weeks and for three weeks against Phlebotomus perniciosus and Lutzomyia longipalpis, for two weeks against mosquitoes (Aedes aegypti) and four weeks against Culex pipiens and against blood-sucking flies (Stomoxys calcitrans) for 4 weeks.
CONTRAINDICATIONS: Due to lack of available data, the product should not be used in puppies under 7 weeks of age and weighing less than 1.5 kg. Depending on the dog's weight, appropriate pipette sizes should be used; see the dosage schedule. Do not use in case of hypersensitivity to the active substances and excipients. Do not use on cats.
ADVERSE REACTIONS: In very rare cases, transient skin sensitivity (local itching, scratching, alopecia, and redness at the application site) or transient lethargy may occur in dogs. In very rare cases, dogs may show behavioural changes (agitation, restlessness, whining or rolling), gastrointestinal symptoms (vomiting, diarrhoea, hypersalivation, decreased appetite), and neurological signs such as unsteady gait and trembling in dogs sensitive to permethrin. The signs are transient and resolve without additional treatment. Poisoning due to accidental oral ingestion of the product by the dog is unlikely but may occur in very rare cases. In such cases, symptoms such as tremor and lethargy may occur. Treatment is symptomatic. There is no known specific antidote.
DOSAGE FOR EACH ANIMAL SPECIES, METHOD AND ROUTE OF ADMINISTRATION: The recommended minimum dose is: 10 mg/kg body weight imidacloprid and 50 mg/kg body weight permethrin. For dogs with a body weight up to 10 kg, the dog should be in an upright (standing) position. Part the dog's hair in the area of the back, between the shoulder blades, until the skin is visible. Place the tip of the pipette on the skin and squeeze out its entire contents. For dogs with a body weight over 10 kg, the dog should be in an upright (standing) position, the entire contents of the pipette should be applied evenly at four points along the dorsal line, from the area between the shoulder blades to the base of the tail. At each point, the hair should be parted until the skin is visible. Place the tip of the pipette on the skin and carefully squeeze out some of the contents. To avoid product run-off, do not apply a large amount at one point.
ADDITIONAL INFORMATION: Advantix® Spot-on is an ectoparasiticide for topical use, containing imidacloprid and permethrin. This combination acts as an insecticide, acaricide, and repellent. Imidacloprid is effective against adult fleas and all larval stages of fleas. In addition to the efficacy of imidacloprid against adult specimens, larvicidal efficacy in treated animals has also been demonstrated. Flea larvae in the immediate environment of the dog die after contact with the treated animal. The product provides repellent activity (protects against bites) against ticks, sandflies, and mosquitoes, thereby reducing the risk of transmission of vector-borne diseases in dogs, such as borreliosis, rickettsiosis, ehrlichiosis, and leishmaniasis.
