Improved gastrointestinal health care
Flavoring
Pro-Kolin Advanced contains new and improved flavorings for dogs (liver) and
cats (chicken). Both flavorings are artificial, contain no proteins or allergens,
and can be used in animals with known hypersensitivity.
Directions for use
• Easy-to-use syringe
• New and improved formula
• New, highly palatable, improved flavoring –
different flavors for dogs and cats!
Apply directly into the mouth, for as long as
needed. Pro-Kolin Advanced can
be given up to three times daily, depending on
the severity of the condition.
Probiotics
Pro-Kolin Advanced contains the EU-registered probiotic bacterium Enterococcus faecium
(NCIMB 10415) 4b1707. Enterococcus faecium in Pro-Kolin Advanced has been shown to survive
passage through the digestive tract for maximum efficacy.
Prebiotics
Preplex® prebiotics is a combination of two different types of prebiotics –
fructo-oligosaccharides (FOS) and acacia (gum arabic), which is unique
to Protexin Veterinary. This combination ensures that Pro-Kolin Advanced
stimulates the growth of beneficial bacteria in different areas of the
digestive tract:
Beginning of the large intestine – FOS reach the large
intestine intact, as they are not absorbed by enzymes in the small
intestine. In the large intestine, some beneficial bacteria (Bifidobacterium
spp. and Lactobacillus spp.) readily ferment FOS, leading to
an increase in their number. As FOS have a low molecular
weight, they are utilized in this part of the large intestine.
End of the large intestine – Gum arabic has a complex
branched structure and ferments more slowly in the end of the
large intestine.
Pectin
Pectin is a soluble fiber that quickly
ferments in the large intestine. Alongside its action
as an effective prebiotic, pectin is also known for its soothing
effect on the intestinal mucosa.
Pro-Kolin Advanced
Psyllium
Psyllium is a soluble dietary fiber and has the ability to absorb
excess water in the digestive tract, forming a viscous, gel-like
substance. This increases the viscosity of the feces, which helps
to soothe and normalize transit time in the intestines.
Binding agents
Pro-Kolin Advanced contains pharmaceutical
grade clay, which acts as a binding
agent and supports normal
digestive functions. Different
forms of clay have different properties,
which affect their absorption
and adsorption capabilities:
Absorption – excess liquids in the
gastrointestinal tract enter the
clay molecules.
Adsorption – the ability to bind
compounds, bacteria, viruses and
enterotoxins to the outer surface of
the clay molecules.
The use of a combination of kaolin and montmorillonite provides an optimal balance
between absorption and adsorption and offers a dual benefit for the animal.
Beta-glucans
Beta-glucans, especially those with 1,3/1,6 linkages in their chemical structure, have been shown
to stimulate natural immunity. Immune cells, such as macrophages, have dectin-1
receptors that recognize and respond to beta-1,3/1,6-glucans, leading to
increased antimicrobial activity, enhanced cellular defense and improved resistance
to diseases.4,5
Taurine
Contained only in Pro-Kolin Advanced for cats
An essential amino acid for cats and necessary for maintaining many
normal physiological processes, including (but not limited to) vision, digestion,
heart muscle function, and maintaining a healthy immune system. Homemade,
monotonous diets, which may be recommended for cats with digestive
disorders, are often low in taurine. Pro-Kolin Advanced for cats provides a source for
maintaining taurine levels during periods when such diets are recommended.
Clinically proven
Pro-Kolin Advanced is the first product of its kind with clinically proven efficacy. In a study
of 148 dogs with acute diarrhea, Pro-Kolin Advanced significantly improved the clinical picture compared to
those treated with placebo.
Weight Amount Frequency
Pro-Kolin Advanced 15ml & 30ml
<5kg 2ml Twice daily
5-15kg 3ml Twice daily
15-30kg 5ml Twice daily
>30kg 7ml Twice daily
Pro-Kolin Advanced 60ml
25-35kg 6ml Twice daily
35-45kg 8ml Twice daily
>45kg 10ml Twice daily
